Potential of biosynthesized titanium dioxide nanoparticles towards wastewater treatment and antimicrobial activity.

This study reports a green, sustainable, reliable, and cost-effective method for the biosynthesis of titanium dioxide nanoparticles (TiO2NPs) using the leaf and stem extracts of Carissa opaca. The newly synthesized biogenic TiO2NPs were confirmed and characterized using various analytical techniques, such as Fourier transform infrared spectroscopy (FTIR), high-resolution transmission electron microscopy (HRTEM), dynamic light scattering (DLS), zeta potential, X-ray diffraction (XRD), inductively coupled plasma analysis (ICP), and scanning electron microscopy (SEM). Both the electron microscopy, i.e., SEM and HRTEM confirmed the spherical/hexagonal crystalline structure of TiO2NPs with an average particle size range from 72.8 to 84.11 nm. These nanoparticles (NPs) exhibited aggregation and possessed a diverse array of functional groups on their surface. Biosynthesized TiO2NPs showed excellent photocatalytic activity against methylene blue (MB) with decolorizing efficiency of 87.8% and 91.95%, whereas in case of methyl violet (MV), the decolorizing efficiency of 82.1% and 71.9% was observed with nanoparticles synthesized using leaf and stem extract, respectively. The newly synthesized NPs have also shown good antibacterial potential against Klebsiella pneumoniae and Staphylococcus aureus. This new biomimetic approach offers an economical and environmentally benign alternative for the removal of hazardous dyes and may find a place for antimicrobial applications.

Vaginal microbiome: considerations for reproductive health.

The microbial communities are an indispensable part of the human defense system and coexist with humans as symbionts, contributing to the metabolic functions and immune defense against pathogens. An ecologically stable vaginal microbiota is dominated by Lactobacillus species, which plays an important role in the prevention of genital infections by controlling the vaginal pH, reducing glycogen to lactic acid, and stimulating bacteriocins and hydrogen peroxide. In contrast, an abnormal vaginal microbial composition is associated with an increased risk of bacterial vaginosis, trichomoniasis, sexually transmitted diseases, preterm labor and other birth defects. This microbial diversity is affected by race, ethnicity, pregnancy, hormonal changes, sexual activities, hygiene practices and other conditions. In the present review, we discuss the changes in the microbial community of the vaginal region at different stages of a female's life cycle and its influence on her reproductive health and pathological conditions.

An Insight into Vaginal Microbiome Techniques.

There is a unique microbial community in the female lower genital tract known as the vaginal microbiota, which varies in composition and density and provides significant benefits during pregnancy, reproductive cyclicity, healthy newborn delivery, protection from preterm birth, infections such as UTIs, bacterial vaginosis, and so on, and improves the efficacy of treatments for vaginal cancers. Methods: It is necessary to know how the vaginal microbiome is composed in order to make an accurate diagnosis of the diseases listed above. A microbiome's members are difficult to classify, and the way microbial communities function and influence host-pathogen interactions are difficult to understand. More and more metagenomic studies are able to unravel such complexities due to advances in high-throughput sequencing and bioinformatics. When it comes to vaginal microbiota research, we'll be looking at the use of modern techniques and strategies that can be used to investigate variations in vaginal microbiota in order to detect diseases earlier, better treat vaginal disorders, and boost women's health. Discussion: The discussed techniques and strategies may improve the treatment of vaginal disorders and may be beneficial for women's overall health.

Degradation of synthetic dyes using nanoparticles: a mini-review.

The industrial revolution has marked a strong impact on financial upgradation of several countries, and increase in the industrial establishment globally has direct impact on environment because of the release of unwanted product in air and inside the water bodies. The use of dyes has increased tremendously in various industries ranging from food, leather, textile, paper, cosmetic, pharmaceuticals, etc. The problem has emerged due to disposing of the dyes in the open environment, and mostly it is disposed along with the industrial wastes into the water bodies, which becomes harmful for animals, aquatic life and human health. This review highlights the role of the nanoparticles particularly biosynthesized nanoparticles for eliminating the dyes from the industrial wastewater. There are several methods for the synthesis of nanoparticle including physical, chemical and green synthesis of nanoparticles commonly known as biological method. Among all, the biological method is considered as the rapid, easy, eco-friendly and is being performed at mild conditions. The uses of nanoparticles for removal of dyes from water minimize the hazardous impact and thus considered to be the best approach as far as water quality and safety of environment is concerned.

Bioactive compounds and probiotics-a ray of hope in COVID-19 management.

The use of bioactive compounds and probiotic bacteria against the viral diseases in human is known for a long time. Anti-viral, anti-inflammatory and anti-allergic properties of bioactive compounds and bacteria with probiotic properties in respiratory viral diseases may have significance to enhance immunity. This review highlights some of the important bioactive compounds and probiotic bacteria, suggesting them as a ray of hope in the milieu of the COVID-19 management.